Bufo Alvarius

In the vast expanse of the Sonoran Desert, where ancient wisdom flows, resides the indigenous community of the Comcaac people, also known as the Seri tribe. Their spiritual practices are deeply rooted in their relationship with the natural world, and one aspect of their traditional spirituality involves the use of the enzyme of the Bufo Alvarius, a species of toad commonly referred to as the Colorado River toad or the Sonoran Desert toad.

The spiritual use of this enzyme among the Comcaac people is not taken lightly. It is considered a sacred practice that requires proper initiation, preparation, guidance, and respect for the toad, its life, and the spiritual realm it represents. The ceremonies are conducted with the utmost reverence, emphasizing the importance of intention, humility, and a deep understanding of the interconnectedness of all beings.

The Bufo Alvarius toad is handled with utmost respect and care by the Comcaac people. They are not hurt in the process of extracting the enzyme. By taking part in our retreats, you support preservation projects for this sacred medicine for future generations.


The experience induced by Bufo Alvarius is highly intense and transformative, often leading to profound spiritual insights, expanded consciousness, and a sense of unity with the universe. The Comcaac people believe that it allows them to connect with the spiritual realm and receive guidance, healing, and wisdom from their ancestors and the natural forces that govern their lives. We honor the tradition of the Comcaac people, their wisdom, and the ancient ways embedded in this practice.


Any serotonin enhancing medication is advisable not to be taken with Bufo Alvarius; this includes the vast majority of antidepressants (SSRI’s, tricyclics, MAOI’s, etc). Bufo Alvarius should not be combined with red meat, alcohol or recreational substances such as marijuana for at least 24 hours before your ceremony. Bufo Alvarius should be avoided during pregnancy and breastfeeding and for those with mental illness, high blood pressure and heart conditions. Please contact your medical professional for guidance.


While we believe in the spiritual healing and transformative potential of the sacred medicine of Bufo Alvarius, we encourage you to conduct your own independent research if you like to learn more about the science and other aspects behind it.


Bufo Alvarius Retreat – Colorado

With Ursula Sefic, Eva Evers and Sarah Howat

June 14 - 17, 2024
South Park County, Colorado
Our retreat center is nestled on 5 acres of aspen groves, towering evergreens, and picturesque rock outcrops. Situated in South Park County, Colorado, breathtaking views of the Mosquito Range peaks are visible from every vantage point. The center exudes intimacy with ample natural light and an open communal space. A spacious deck with seating provide space to gather with others or enjoy a quiet moment. Secluded seating spots tucked in around the property are a favorite for meditation and solace. The ceremony will take place indoors, by the fireplace, surrounded in the majestic beauty of the natural surroundings. . WHAT…

Seri Culture Immersion Excursion (Bufo Alvarius)

With Luis Miguel Lopez, Alfonso Morales Romero and Eva Evers

November 11 - 15, 2024
Sonora, Mexico
Embark on a transformative 6-day spiritual journey with the Seri people, indigenous custodians of the ancient Sonoran Desert, and immerse yourself in their profound spiritual wisdom and culture that dates back thousands of years. This unique retreat offers an opportunity to connect deeply with nature, experience traditional and Bufo Alvarius ceremonies, and gain insights into the Seri way of life.