Bufo Alvarius

In the vast expanse of the Sonoran Desert, where ancient wisdom flows, resides the indigenous community of the Comcaac people, also known as the Seri tribe. Their spiritual practices are deeply rooted in their relationship with the natural world, and one aspect of their traditional spirituality involves the use of the enzyme of the Bufo Alvarius, a species of toad commonly referred to as the Colorado River toad or the Sonoran Desert toad.

The spiritual use of this enzyme among the Comcaac people is not taken lightly. It is considered a sacred practice that requires proper initiation, preparation, guidance, and respect for the toad, its life, and the spiritual realm it represents. The ceremonies are conducted with the utmost reverence, emphasizing the importance of intention, humility, and a deep understanding of the interconnectedness of all beings.

The Bufo Alvarius toad is handled with utmost respect and care by the Comcaac people. They are not hurt in the process of extracting the enzyme. By taking part in our retreats, you support preservation projects for this sacred medicine for future generations.


The experience induced by Bufo Alvarius is highly intense and transformative, often leading to profound spiritual insights, expanded consciousness, and a sense of unity with the universe. The Comcaac people believe that it allows them to connect with the spiritual realm and receive guidance, healing, and wisdom from their ancestors and the natural forces that govern their lives. We honor the tradition of the Comcaac people, their wisdom, and the ancient ways embedded in this practice.


Any serotonin enhancing medication is advisable not to be taken with Bufo Alvarius; this includes the vast majority of antidepressants (SSRI’s, tricyclics, MAOI’s, etc). Bufo Alvarius should not be combined with red meat, alcohol or recreational substances such as marijuana for at least 24 hours before your ceremony. Bufo Alvarius should be avoided during pregnancy and breastfeeding and for those with mental illness, high blood pressure and heart conditions. Please contact your medical professional for guidance.


While we believe in the spiritual healing and transformative potential of the sacred medicine of Bufo Alvarius, we encourage you to conduct your own independent research if you like to learn more about the science and other aspects behind it.


Comcaac (Seri) Bufo Alvarius Retreat

With Luis Miguel Lopez, Alfonso Morales Romero, Eva Evers and Agder Sanchez Palacios

November 5 - 10, 2023
Sonora, Mexico
We are grateful for the opportunity to share the beautiful medicine work of the Comcaac (Seri) people from Sonora, Mexico. The Bufo ceremony is one of incredible intimacy, great depth, and beauty. It is an environment conducive to the free and unrestricted expression of the deep and abiding Love that unfolds during a journey of […]